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Guanabenz


Mechanism of action:

Guanabenz is an α₂-adrenergic agonist. Guanabenz activates α₂ receptors in the brainstem, especially in the medullary vasomotor center, inhibiting the release of norepinephrine and reducing sympathetic stimulation of the heart and blood vessels. This leads to a decrease in heart rate and cardiac output, thereby lowering peripheral vascular resistance and circulatory workload.

Reference(s):

1. Piletz JE et al. (1993). Nonadrenergic imidazoline binding sites on human platelets. J Pharmacol Exp Ther. 


2. Bockman CS et al. (1993). Binding and functional characterization of alpha-2 adrenergic receptor subtypes on pig vascular endothelium. J Pharmacol Exp Ther. 


3. Bockman CS et al. (1996). Alpha-2 adrenoceptor subtype causing nitric oxide-mediated vascular relaxation in rats. J Pharmacol Exp Ther.

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