The Sound of Evolution
Ibutilide
Mechanism of action:
Ibutilide can increase the late sodium current component during the repolarization period of cardiac myocytes, thereby increasing late inward positive current and prolonging the duration of the cardiac action potential, mainly manifesting as delayed phase 3 repolarization. Ibutilide can also inhibit the rapid delayed rectifier potassium current, reducing potassium efflux and further prolonging action potential duration.
Reference(s):
1. Doggrell SA et al. (2005). Ibutilide—recent molecular insights and accumulating evidence for use in atrial flutter and fibrillation. Expert Opin Investig Drugs.
2. Foster RH et al. (1997). Ibutilide: a review of its pharmacological properties and clinical potential in the acute management of atrial flutter and fibrillation. Drugs.
3. Chen X et al. (2002). TTD: Therapeutic Target Database. Nucleic Acids Res.