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The Sound of Evolution
Imipramine
Mechanism of action:
Imipramine is a tricyclic antidepressant and belongs to the dibenzazepine derivatives. Imipramine inhibits the function of the norepinephrine transporter and the serotonin transporter, increasing the concentrations of norepinephrine and serotonin (5-HT) in the synaptic cleft. This enhances central nervous system neurotransmission and is associated with reducing depressive symptoms.
Reference(s):
1. American Psychiatric Association et al. (2006). Treatment of patients with eating disorders, third edition. Am J Psychiatry.
2. Low PA et al. (1998). Symptomatic treatment of painful neuropathy. JAMA.
3. Sallee FR et al. (1990). Clinical pharmacokinetics of imipramine and desipramine. Clin Pharmacokinet.
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