The Sound of Evolution
Indapamide
Mechanism of action:
Indapamide is a thiazide-like diuretic. Indapamide mainly acts on the distal convoluted tubule of the kidney, inhibiting the Na⁺/Cl⁻ cotransporter and thereby reducing the reabsorption of sodium and chloride ions. This promotes the excretion of sodium and water, lowers blood volume and cardiac output, and reduces circulatory load and peripheral vascular resistance.
Reference(s):
1. Dong DL et al. (2006). Indapamide induces apoptosis of GH3 pituitary cells independently of its inhibition of voltage-dependent K⁺ currents. Eur J Pharmacol.
2. Chaffman M et al. (1984). Indapamide: a review of its pharmacodynamic properties and therapeutic efficacy in hypertension. Drugs.
3. Bataillard A et al. (1999). Pharmacological properties of indapamide: rationale for use in hypertension. Clin Pharmacokinet.