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The Sound of Evolution
Indomethacin
Mechanism of action:
Indomethacin is an indoleacetic acid derivative. It inhibits cyclooxygenase, including COX-1 and COX-2, thereby blocking the conversion of arachidonic acid into prostaglandins and reducing prostaglandin-mediated inflammatory signaling, pain sensitization, and fever responses.
Reference(s):
1. Lucas S et al. (2016). The pharmacology of indomethacin. Headache.
2. Helleberg L et al. (1981). Clinical pharmacokinetics of indomethacin. Clin Pharmacokinet.
3. Nalamachu S et al. (2014). Role of indomethacin in acute pain and inflammation management: a review of the literature. Postgrad Med.
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