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Irbesartan


Mechanism of action:

Irbesartan is an angiotensin II receptor blocker. Angiotensin II normally promotes contraction of vascular smooth muscle through the AT₁ receptor, leading to increased blood pressure. By blocking the AT₁ receptor, irbesartan causes peripheral vasodilation, reduces systemic vascular resistance, and suppresses angiotensin II-mediated pressor signaling.

Reference(s):

1. Lewis EJ et al. (2001). Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes. N Engl J Med. 


2. Croom KF et al. (2004). Irbesartan: a review of its use in hypertension and in the management of diabetic nephropathy. Drugs. 


3. Chando TJ et al. (1998). Biotransformation of irbesartan in man. Drug Metab Dispos.

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