Ivermectin

Ivermectin is an avermectin derivative. It binds with high affinity to glutamate-gated Cl⁻ channels on the nerve and muscle cell membranes of parasites and activates them. These channels are widely present in invertebrates, whereas human cells lack the same type of glutamate-gated chloride channel. Once activated, large amounts of chloride ions flow into the cell, causing excessive membrane hyperpolarization and ultimately leading to flaccid paralysis of the parasite.