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Ixabepilone


Mechanism of action:

Ixabepilone is an epothilone microtubule inhibitor. It binds to β-tubulin in microtubules and excessively stabilizes microtubules, preventing their normal depolymerization and thereby blocking the completion of mitosis. Once microtubule dynamics are disrupted, the cell cycle is arrested in the G₂/M phase, eventually triggering apoptosis.

Reference(s):

1. Vahdat L et al. (2008). Ixabepilone: a novel antineoplastic agent with low susceptibility to multiple tumor resistance mechanisms. Oncologist. 


2. Denduluri N et al. (2008). Ixabepilone for the treatment of solid tumors: a review of clinical data. Expert Opin Investig Drugs. 


3. Goodin S et al. (2008). Ixabepilone: a novel microtubule-stabilizing agent for the treatment of metastatic breast cancer. Am J Health Syst Pharm.

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