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The Sound of Evolution
Ketoprofen
Mechanism of action:
Ketoprofen is a propionic acid derivative. It inhibits cyclooxygenase, including COX-1 and COX-2, thereby blocking the conversion of arachidonic acid into prostaglandins and reducing prostaglandin-mediated inflammatory signaling, pain sensitization, and fever responses.
Reference(s):
1. Kantor TG et al. (1986). Ketoprofen: a review of its pharmacologic and clinical properties. Pharmacotherapy.
2. Mazieres B et al. (2005). Topical ketoprofen patch. Drugs R D.
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