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The Sound of Evolution
Ketorolac
Mechanism of action:
Ketorolac is a pyrroloacetic acid derivative. It inhibits cyclooxygenase, including COX-1 and COX-2, thereby blocking the conversion of arachidonic acid into prostaglandins and reducing prostaglandin-mediated inflammatory signaling and pain sensitization.
Reference(s):
1. Brocks DR et al. (1992). Clinical pharmacokinetics of ketorolac tromethamine. Clin Pharmacokinet.
2. Litvak KM et al. (1990). Ketorolac, an injectable nonnarcotic analgesic. Clin Pharm.
3. Macario A et al. (2001). Ketorolac in the era of cyclo-oxygenase-2 selective nonsteroidal anti-inflammatory drugs: a systematic review of efficacy, side effects, and regulatory issues. Pain Med.
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