The Sound of Evolution
Lansoprazole
Mechanism of action:
Lansoprazole is a proton pump inhibitor. After entering gastric parietal cells, it is converted within the highly acidic secretory canaliculi into its active sulfenamide form. Active lansoprazole then forms a covalent bond with the H⁺/K⁺-ATPase proton pump on the apical membrane of parietal cells, blocking hydrogen ion secretion into the gastric lumen and thereby suppressing gastric acid secretion.
Reference(s):
1. Matheson AJ et al. (2001). Lansoprazole: an update of its place in the management of acid-related disorders. Drugs.
2. Shin JM et al. (2008). Pharmacology of proton pump inhibitors. Curr Gastroenterol Rep.
3. Shin JM et al. (2013). Pharmacokinetics and pharmacodynamics of the proton pump inhibitors. J Neurogastroenterol Motil.