The Sound of Evolution
Latanoprost
Mechanism of action:
Latanoprost is a prostaglandin F₂α analog. It is a prodrug that is absorbed through the cornea and hydrolyzed by esterases within the eye into its active form, latanoprost acid. Active latanoprost acid binds to prostaglandin F receptors on the ciliary muscle and sclera, initiating downstream signaling. By inducing matrix metalloproteinase expression, it alters the extracellular matrix structure of the ciliary muscle, allowing aqueous humor to drain more easily through the uveoscleral pathway and thereby effectively lowering intraocular pressure.
Reference(s):
1. Hara T et al. (2001). Increased iris pigmentation after use of latanoprost in Japanese brown eyes. Nippon Ganka Gakkai Zasshi.
2. Patel SS et al. (1996). Latanoprost: a review of its pharmacological properties, clinical efficacy and tolerability in the management of primary open-angle glaucoma and ocular hypertension. Drugs Aging.
3. Alm A et al. (2014). Latanoprost in the treatment of glaucoma. Clin Ophthalmol.