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The Sound of Evolution
Letrozole
Mechanism of action:
Letrozole is a non-steroidal aromatase inhibitor. Aromatase is responsible for converting androstenedione into estrone and testosterone into estradiol. By inhibiting aromatase activity, letrozole lowers estrogen levels in the body and thereby reduces estrogen receptor-driven stimulation of tumor proliferation.
Reference(s):
1. Bhatnagar AS et al. (1990). Highly selective inhibition of estrogen biosynthesis by CGS 20267, a new non-steroidal aromatase inhibitor. J Steroid Biochem Mol Biol.
2. Bhatnagar AS et al. (2007). The discovery and mechanism of action of letrozole. Breast Cancer Res Treat.
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