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The Sound of Evolution
Liothyronine
Mechanism of action:
Liothyronine is a thyroid hormone preparation and is the synthetic form of triiodothyronine (T3). After entering the cell, liothyronine binds to TRα and TRβ receptors in the nucleus, forming a receptor-hormone complex. This complex then binds to thyroid hormone response elements on DNA and regulates transcription of multiple genes, affecting protein synthesis and cellular metabolic function, increasing basal metabolic rate, and promoting carbohydrate, lipid, and protein metabolism.
Reference(s):
1. Jonklaas J et al. (2015). Single-dose T3 administration: kinetics and effects on biochemical and physiological parameters. Ther Drug Monit.
2. Sullivan K et al. (2009). Nurse's drug handbook (8th ed.). Jones and Bartlett Publishers.
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