top of page
The Sound of Evolution
Liraglutide
Mechanism of action:
Liraglutide is a glucagon-like peptide-1 receptor agonist. By binding to GLP-1 receptors on pancreatic β cells, liraglutide promotes glucose-dependent insulin secretion while also suppressing glucagon release, delaying gastric emptying, and reducing appetite, thereby lowering postprandial and fasting glucose-related burden.
Reference(s):
1. Malm-Erjefalt M et al. (2010). Metabolism and excretion of the once-daily human glucagon-like peptide-1 analog liraglutide in healthy male subjects and its in vitro degradation by dipeptidyl peptidase IV and neutral endopeptidase. Drug Metab Dispos.
2. Knudsen B et al. (n.d.). The Discovery and Development of Liraglutide and Semaglutide. Frontiers in Endocrinology.
bottom of page