The Sound of Evolution
Lomefloxacin
Mechanism of action:
Lomefloxacin is a second-generation fluoroquinolone antibiotic and an inhibitor of DNA gyrase (bacterial topoisomerase II). Lomefloxacin binds to the DNA gyrase-DNA complex and prevents the re-ligation of cleaved DNA generated by DNA gyrase. This leads to the accumulation of DNA breaks, halts DNA replication and transcription, and ultimately causes bacterial death. It may also inhibit topoisomerase IV.
Reference(s):
1. Takenouchi T et al. (1995). Incidence of various gyrA mutants in 451 Staphylococcus aureus strains isolated in Japan and their susceptibilities to 10 fluoroquinolones. Antimicrob Agents Chemother.
2. Drusano GL et al. (1993). Pharmacodynamics of a fluoroquinolone antimicrobial agent in a neutropenic rat model of Pseudomonas sepsis. Antimicrob Agents Chemother.
3. Gushchin AE et al. (1999). Role of mutations in parC and gyrA in forming resistance of Mycoplasma hominis to fluoroquinolones. Mol Gen Mikrobiol Virusol.