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The Sound of Evolution
Losartan
Mechanism of action:
Losartan is an angiotensin II receptor blocker. When angiotensin II binds to the AT1 receptor, it causes strong contraction of vascular smooth muscle. Losartan antagonizes the AT1 receptor, thereby relaxing peripheral blood vessels, reducing peripheral resistance, and lowering blood pressure.
Reference(s):
1. Sica DA et al. (2005). Clinical pharmacokinetics of losartan. Clin Pharmacokinet.
2. Zhou SF et al. (2009). Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem.
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