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The Sound of Evolution
Loteprednol
Mechanism of action:
Loteprednol is a corticosteroid. After entering the cell, loteprednol binds to glucocorticoid receptors in the cytoplasm, forming a drug-receptor complex that then enters the nucleus. This increases the expression of anti-inflammatory genes such as annexin A1, while suppressing the transcription of inflammatory genes mediated by inflammatory transcription factors such as NF-κB and AP-1.
Reference(s):
1. Yasir M et al. (n.d.). Corticosteroid Adverse Effects.
2. Czock D et al. (2005). Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids. Clin Pharmacokinet.
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