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The Sound of Evolution
Loxapine
Mechanism of action:
Loxapine is a dibenzoxazepine derivative. Loxapine blocks D2 receptors in the mesolimbic pathway, thereby reducing excessive dopamine activity. It also antagonizes 5-HT2A receptors, affecting dopamine- and serotonin-related neurotransmission, and in some individuals may reduce emotional and behavioral agitation. However, the risk of extrapyramidal side effects still requires attention.
Reference(s):
1. Glazer WM et al. (1999). Does loxapine have "atypical" properties? Clinical evidence. J Clin Psychiatry.
2. Cheung SW et al. (1991). Simultaneous quantitation of loxapine, amoxapine and their 7- and 8-hydroxy metabolites in plasma by high-performance liquid chromatography. J Chromatogr.
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