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Lutropin alfa


Mechanism of action:

Lutropin alfa is a recombinant human luteinizing hormone. Lutropin alfa acts on theca cells in ovarian follicles and promotes the conversion of cholesterol into androgens such as androstenedione. These androgens are then transported to granulosa cells in the ovary, where they are converted into estradiol through aromatization under the stimulation of follicle-stimulating hormone (FSH), thereby supporting normal follicular maturation.

Reference(s):

1. Blanchard J et al. (1975). Gastrointestinal absorption. I. Mechanisms. Am J Pharm Sci Support Public Health. 


2. Louvet JP et al. (1975). Effects of human chorionic gonadotropin, human interstitial cell stimulating hormone and human follicle-stimulating hormone on ovarian weights in estrogen-primed hypophysectomized immature female rats. Endocrinology. 


3. Nielsen MS et al. (2001). Comparison of several one-step home urinary luteinizing hormone detection test kits to OvuQuick. Fertil Steril.

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