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The Sound of Evolution
Maprotiline
Mechanism of action:
Maprotiline is a tetracyclic antidepressant. Maprotiline primarily inhibits the norepinephrine transporter, increasing norepinephrine concentrations in the synaptic cleft and enhancing norepinephrine-mediated signaling in the central nervous system. In contrast, its inhibitory effect on the serotonin transporter is very weak.
Reference(s):
1. Saba W et al. (2007). [11C]LBT-999: a suitable radioligand for investigation of extra-striatal dopamine transporter with PET. Synapse.
2. Arai S et al. (2003). Chronic inhibition of the norepinephrine transporter in the brain participates in seizure sensitization to cocaine and local anesthetics. Brain Res.
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