The Sound of Evolution
Maraviroc
Mechanism of action:
Maraviroc is a CCR5 antagonist. Maraviroc binds to CCR5 (C-C chemokine receptor 5) on the cell membrane and alters its conformation, preventing it from being recognized by the HIV-1 envelope glycoprotein gp120. This blocks viral entry into the cell and therefore prevents viral replication. Its activity is limited against viral strains that use CXCR4 as a co-receptor.
Reference(s):
1. Chen X et al. (2002). TTD: Therapeutic Target Database. Nucleic Acids Res.
2. Levy JA et al. (2009). HIV pathogenesis: 25 years of progress and persistent challenges. AIDS.
3. Agrawal-Gamse C et al. (2009). Adaptive mutations in a human immunodeficiency virus type 1 envelope protein with a truncated V3 loop restore function by improving interactions with CD4. J Virol.