The Sound of Evolution
Mecamylamine
Mechanism of action:
Mecamylamine is a ganglionic blocker and a nicotinic acetylcholine receptor antagonist. Mecamylamine blocks nicotinic acetylcholine receptors located in the autonomic ganglia (both sympathetic and parasympathetic), mainly the α3β4 subtype, thereby inhibiting acetylcholine-mediated signal transmission between preganglionic and postganglionic neurons.
Reference(s):
1. Chen X et al. (2002). TTD: Therapeutic Target Database. Nucleic Acids Res.
2. Struthers AM et al. (2009). Mecamylamine, dihydro-beta-erythroidine, and dextromethorphan block conditioned responding evoked by the conditional stimulus effects of nicotine. Pharmacol Biochem Behav.
3. Shytle RD et al. (2002). Mecamylamine (Inversine): an old antihypertensive with new research directions. J Hum Hypertens.