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The Sound of Evolution
Mecasermin
Mechanism of action:
Mecasermin is a recombinant human insulin-like growth factor-1. Mecasermin binds to the IGF-1 receptor on the cell surface and triggers receptor autophosphorylation, which subsequently activates downstream signaling pathways such as PI3K-Akt and MAPK. These signals together promote the growth of bone, cartilage, and other peripheral tissues.
Reference(s):
1. Keating GM et al. (2008). Mecasermin. BioDrugs.
2. Rosenbloom AL et al. (2009). Mecasermin (recombinant human insulin-like growth factor I). Adv Ther.
3. Kemp SF et al. (2009). Insulin-like growth factor-I deficiency in children with growth hormone insensitivity: current and future treatment options. BioDrugs.
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