The Sound of Evolution
Meclofenamate
Mechanism of action:
Meclofenamate is an anthranilic acid derivative. Meclofenamate inhibits cyclooxygenase, including both COX-1 and COX-2, thereby blocking the conversion of arachidonic acid into prostaglandins and thromboxanes. This reduces prostaglandin- and thromboxane-mediated inflammatory signaling and pain sensitization.
Reference(s):
1. Perez-Vizcaino F et al. (2002). Postnatal maturation in nitric oxide-induced pulmonary artery relaxation involving cyclooxygenase-1 activity. Am J Physiol Lung Cell Mol Physiol.
2. Shiels IA et al. (2000). Lyprinol: anti-inflammatory and uterine-relaxant activities in rats, with special reference to a model for dysmenorrhoea. Allerg Immunol (Paris).
3. Wilson JE et al. (2004). Determination of expression of cyclooxygenase-1 and -2 isozymes in canine tissues and their differential sensitivity to nonsteroidal anti-inflammatory drugs. Am J Vet Res.