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Mefenamic acid


Mechanism of action:

Mefenamic acid is an anthranilic acid derivative. Mefenamic acid inhibits cyclooxygenase, including COX-1 and COX-2, thereby preventing the conversion of arachidonic acid into prostaglandins and reducing prostaglandin-mediated inflammatory signaling, pain sensitization, and fever responses.

Reference(s):

1. Gierse JK et al. (1995). Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem J. 


2. Bhat AS et al. (2007). Interaction between inhibitors of inducible nitric oxide synthase and cyclooxygenase in adjuvant-induced arthritis in female albino rats: an isobolographic study. Eur J Pharmacol. 


3. Bhat AS et al. (2005). Interaction between inhibitors of inducible nitric oxide synthase and cyclooxygenase in Brewer's yeast induced pyrexia in mice: an isobolographic study. Eur J Pharmacol.

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