The Sound of Evolution
Megestrol acetate
Mechanism of action:
Megestrol acetate is a synthetic progestin and a derivative of progesterone. Megestrol acetate binds to progesterone receptors and forms a drug-receptor complex that enters the nucleus and regulates the transcription of specific genes, producing physiological responses similar to those of the luteal phase. Megestrol acetate can also act on the hypothalamus and alter the balance of neuropeptides involved in appetite regulation. It is thought to be associated with increased neuropeptide Y (NPY) activity and suppression of inflammatory cytokines such as TNF-α and IL-1, ultimately influencing central regulation of appetite and energy intake.
Reference(s):
1. Berenstein EG et al. (2005). Megestrol acetate for the treatment of anorexia-cachexia syndrome. Cochrane Database Syst Rev.
2. Pascual Lopez A et al. (2004). Systematic review of megestrol acetate in the treatment of anorexia-cachexia syndrome. J Pain Symptom Manage.
3. Rao GG et al. (2006). Hormonal therapy in epithelial ovarian cancer. Expert Rev Anticancer Ther.