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Mephenoxalone


Mechanism of action:

Mephenoxalone is a centrally acting muscle relaxant and structurally belongs to the oxazolidinone class of derivatives. Its exact molecular mechanism has not been fully clarified, but its action is thought to arise mainly from suppression of muscle tone reflexes at the central nervous system level rather than from direct effects on the neuromuscular junction or skeletal muscle itself. Mephenoxalone mainly acts in the spinal cord and brainstem, where it suppresses polysynaptic reflex pathways involved in muscle tone and spasm formation, reduces excessive motor neuron firing, and may thereby promote muscle relaxation and decrease pain-related signal output.

Reference(s):

Gray WD et al. (1961). Neuropharmacological actions of mephenoxalone. Arch Int Pharmacodyn Ther.

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