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The Sound of Evolution
Mesoridazine
Mechanism of action:
Mesoridazine is a phenothiazine derivative and the major active metabolite of thioridazine. Mesoridazine blocks dopamine D₂ receptors in the mesolimbic pathway, reducing excessive dopamine activity and thereby decreasing psychotic symptoms associated with excessive dopaminergic signaling, such as hallucinations, delusions, and disorganized thinking.
Reference(s):
1. Chen X et al. (2002). TTD: Therapeutic Target Database. Nucleic Acids Res.
2. Burstein ES et al. (2005). Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonist. J Pharmacol Exp Ther.
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