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The Sound of Evolution
Methocarbamol
Mechanism of action:
Methocarbamol is a centrally acting skeletal muscle relaxant and a carbamate derivative. Its exact mechanism remains unclear, but it is thought to suppress polysynaptic reflex activity at the spinal cord and brainstem levels, thereby reducing muscle spasms. Methocarbamol does not directly block the muscle contraction mechanism.
Reference(s):
1. Sica DA et al. (1990). Pharmacokinetics and protein binding of methocarbamol in renal insufficiency and normals. Eur J Clin Pharmacol.
2. Bruce RB et al. (1971). Metabolism of methocarbamol in the rat, dog, and human. J Pharm Sci.
3. Witenko C et al. (2014). Considerations for the appropriate use of skeletal muscle relaxants for the management of acute low back pain. P T.
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