top of page
The Sound of Evolution
Methohexital
Mechanism of action:
Methohexital is a barbiturate derivative. Methohexital binds to the barbiturate binding site of the GABA_A receptor and enhances the action of the inhibitory neurotransmitter GABA (γ-aminobutyric acid). It prolongs the opening time of chloride channels, allowing more chloride ions to enter neurons and causing marked hyperpolarization of the cell membrane.
Reference(s):
1. Koltchine VV et al. (1996). Chimeric GABAA/glycine receptors: expression and barbiturate pharmacology. Neuropharmacology.
2. Chen X et al. (2002). TTD: Therapeutic Target Database. Nucleic Acids Res.
3. Zhou Y et al. (2024). TTD: Therapeutic Target Database describing target druggability information. Nucleic Acids Res.
bottom of page