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The Sound of Evolution
Methoxyflurane
Mechanism of action:
Methoxyflurane is a fluorinated ether derivative. Its receptor mechanism has not been fully defined, but it is known to enhance the inhibitory actions of GABA_A and glycine receptors, increasing neuronal responsiveness to inhibitory signals and reducing central nervous system excitability.
Reference(s):
1. Moody EJ et al. (1988). Modulation of the benzodiazepine/gamma-aminobutyric acid receptor chloride channel complex by inhalation anesthetics. J Neurochem.
2. Martin DC et al. (1995). Volatile anesthetics and glutamate activation of N-methyl-D-aspartate receptors. Biochem Pharmacol.
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