The Sound of Evolution
Methylenedioxymethamphetamine
Mechanism of action:
Methylenedioxymethamphetamine is a phenethylamine derivative. Methylenedioxymethamphetamine enters neurons and acts on the serotonin transporter, switching it from "reuptake mode" to "reverse transport," which causes a large release of serotonin into the synaptic cleft.
Reference(s):
1. Freudenmann RW et al. (2006). The origin of MDMA (ecstasy) revisited: the true story reconstructed from the original documents. Addiction.
2. Jayanthi LD et al. (2005). Regulation of monoamine transporters: influence of psychostimulants and therapeutic antidepressants. AAPS J.
3. Verrico CD et al. (2007). MDMA (Ecstasy) and human dopamine, norepinephrine, and serotonin transporters: implications for MDMA-induced neurotoxicity and treatment. Psychopharmacology (Berl).