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The Sound of Evolution
Methylphenidate
Mechanism of action:
Methylphenidate is a piperidine derivative. Methylphenidate primarily inhibits the dopamine transporter and norepinephrine transporter. As a result, dopamine and norepinephrine cannot be reabsorbed by nerve terminals, leading to increased concentrations of these neurotransmitters in the synaptic cleft and enhanced neuronal stimulation.
Reference(s):
1. Keating GM et al. (2001). Methylphenidate (OROS formulation). CNS Drugs.
2. Markowitz JS et al. (2006). A comprehensive in vitro screening of d-, l-, and dl-threo-methylphenidate: an exploratory study. J Child Adolesc Psychopharmacol.
3. Fone KC et al. (2005). Stimulants: use and abuse in the treatment of attention deficit hyperactivity disorder. Curr Opin Pharmacol.
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