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The Sound of Evolution
Metocurine
Mechanism of action:
Metocurine is a non-depolarizing neuromuscular blocking agent and a bis-quaternary ammonium derivative. Metocurine binds to nicotinic acetylcholine receptors at the motor end-plate and acts as a competitive antagonist against acetylcholine. When metocurine occupies the receptor, acetylcholine cannot trigger sodium influx, and the neuromuscular end-plate cannot generate a depolarizing potential, thereby blocking the generation of muscle action potentials.
Reference(s):
Spacek A et al. (1999). Rocuronium-induced neuromuscular block is affected by chronic carbamazepine therapy. Anesthesiology.
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