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The Sound of Evolution
Metoprolol
Mechanism of action:
Metoprolol is a selective β₁-adrenergic blocker. Metoprolol primarily acts on β₁ receptors in the myocardium and cardiac conduction system, blocking the binding of norepinephrine and epinephrine and weakening sympathetic signaling. This leads to a decrease in heart rate, myocardial contractility, and atrioventricular conduction velocity.
Reference(s):
1. Silberstein SD et al. (2015). Preventive Migraine Treatment. Continuum (Minneap Minn).
2. Bahar MA et al. (2018). The impact of CYP2D6 mediated drug-drug interaction: a systematic review on a combination of metoprolol and paroxetine/fluoxetine. Br J Clin Pharmacol.
3. Regardh CG et al. (1981). Pharmacokinetics of metoprolol in patients with hepatic cirrhosis. Clin Pharmacokinet.
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