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The Sound of Evolution
Micafungin
Mechanism of action:
Micafungin is an echinocandin antifungal agent. Micafungin inhibits β-(1,3)-D-glucan synthase, the enzyme responsible for producing β-(1,3)-D-glucan, which is one of the key components of the fungal cell wall. By blocking β-(1,3)-D-glucan synthesis, micafungin weakens the fungal cell wall and makes fungal cells vulnerable to osmotic stress.
Reference(s):
1. Grover ND et al. (2010). Echinocandins: A ray of hope in antifungal drug therapy. Indian J Pharmacol.
2. Bormann AM et al. (2009). Review of the pharmacology and clinical studies of micafungin. Drug Des Devel Ther.
3. Vehreschild JJ et al. (2006). Micafungin sodium, the second of the echinocandin class of antifungals: theory and practice. Future Microbiol.
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