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Miconazole


Mechanism of action:

Miconazole is an imidazole derivative. Miconazole inhibits fungal lanosterol 14α-demethylase (CYP51), the enzyme responsible for converting lanosterol into ergosterol. When this step is blocked, the fungal cell membrane becomes structurally defective, and lanosterol accumulates because it can no longer be converted, causing toxicity and ultimately suppressing fungal growth or leading to cellular damage.

Reference(s):

1. Taudorf EH et al. (2019). Cutaneous candidiasis - an evidence-based review of topical and systemic treatments to inform clinical practice. J Eur Acad Dermatol Venereol. 


2. Tanenbaum L et al. (1984). 1% sulconazole cream v 2% miconazole cream in the treatment of tinea versicolor. A double-blind, multicenter study. Arch Dermatol. 


3. Pierard GE et al. (2012). Miconazole, a pharmacological barrier to skin fungal infections. Expert Opin Pharmacother.

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