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The Sound of Evolution
Midodrine
Mechanism of action:
Midodrine is a selective α₁-adrenergic agonist. Midodrine is a prodrug that is hydrolyzed in the body into its main active metabolite, desglymidodrine. Desglymidodrine activates α₁ receptors on the smooth muscle of small arteries and veins, triggering vascular smooth muscle contraction, increasing systemic peripheral resistance, and raising blood pressure.
Reference(s):
1. Hebenstreit G et al. (1981). Treatment of hypotension caused by psychopharmacological drugs (author's transl). Wien Med Wochenschr.
2. Tsuda M et al. (2006). Transport characteristics of a novel peptide transporter 1 substrate, antihypotensive drug midodrine, and its amino acid derivatives. J Pharmacol Exp Ther.
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