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The Sound of Evolution
Mifamurtide
Mechanism of action:
Mifamurtide is a lipidated derivative of a muramyl tripeptide analog. Mifamurtide is taken up by phagocytic cells, such as macrophages, and binds to the NOD2 (nucleotide-binding oligomerization domain 2) receptor. This subsequently activates immune-related regulatory pathways such as NF-κB and AP-1, enhancing the activity of macrophages and neutrophils.
Reference(s):
1. Ando K et al. (2011). Mifamurtide for the treatment of nonmetastatic osteosarcoma. Expert Opin Pharmacother.
2. Kager L et al. (2010). Review of mifamurtide in the treatment of patients with osteosarcoma. Ther Clin Risk Manag.
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