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Milnacipran


Mechanism of action:

Milnacipran is a serotonin-norepinephrine reuptake inhibitor. Milnacipran inhibits the norepinephrine transporter and the serotonin transporter, preventing the reuptake of norepinephrine and serotonin. As a result, the concentrations of norepinephrine and serotonin in the synaptic cleft increase, prolonging neurotransmission. Milnacipran inhibits the norepinephrine transporter more strongly than the serotonin transporter.

Reference(s):

1. Leo RJ et al. (2006). Clinical potential of milnacipran, a serotonin and norepinephrine reuptake inhibitor, in pain. Curr Opin Investig Drugs. 


2. Sato S et al. (2006). Efficacy of milnacipran on cognitive dysfunction with post-stroke depression: preliminary open-label study. Psychiatry Clin Neurosci.

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