The Sound of Evolution
Miltefosine
Mechanism of action:
Miltefosine is an alkylphosphocholine derivative. Miltefosine can insert into the parasite cell membrane, destabilizing membrane structure, disrupting membrane permeability, and disturbing ionic balance, making the parasite more vulnerable to osmotic and oxidative stress. Miltefosine also inhibits phosphatidylcholine biosynthesis and suppresses protein kinase C activity, resulting in growth arrest and impaired cellular function in parasites.
Reference(s):
1. Monge-Maillo B et al. (2015). Miltefosine for visceral and cutaneous leishmaniasis: drug characteristics and evidence-based treatment recommendations. Clin Infect Dis.
2. Dorlo TP et al. (2008). Pharmacokinetics of miltefosine in Old World cutaneous leishmaniasis patients. Antimicrob Agents Chemother.
3. Dorlo TP et al. (2012). Miltefosine: a review of its pharmacology and therapeutic efficacy in the treatment of leishmaniasis. J Antimicrob Chemother.