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The Sound of Evolution
Minocycline
Mechanism of action:
Minocycline is a tetracycline antibiotic. Minocycline reversibly binds to the 30S subunit of the bacterial ribosome and prevents aminoacyl-tRNA from binding to the mRNA-ribosome complex. As a result, new amino acids cannot be added to the growing peptide chain, and protein synthesis is inhibited.
Reference(s):
1. Redin GS et al. (1966). Antibacterial activity in mice of minocycline, a new tetracycline. Antimicrob Agents Chemother.
2. Nelis HJ et al. (1982). Metabolism of minocycline in humans. Drug Metab Dispos.
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