top of page
The Sound of Evolution
Minoxidil
Mechanism of action:
Minoxidil is a pyrimidine derivative. The detailed mechanism of minoxidil is not yet fully clear, but it is known to open ATP-sensitive potassium channels, causing hyperpolarization of vascular smooth muscle and leading to vasodilation. Some studies also suggest that minoxidil promotes dermal papilla cell proliferation and suppresses apoptotic signaling.
Reference(s):
Olsen EA et al. (2007). A multicenter, randomized, placebo-controlled, double-blind clinical trial of a novel formulation of 5% minoxidil topical foam versus placebo in the treatment of androgenetic alopecia in men. J Am Acad Dermatol.
bottom of page