top of page
The Sound of Evolution
Mitotane
Mechanism of action:
Mitotane is a derivative related to dichlorodiphenyltrichloroethane (DDT). Mitotane accumulates in the adrenal cortex, especially in the zona fasciculata and zona reticularis, where it causes mitochondrial destruction, membrane disintegration, and necrosis of steroid-producing cells. As a result, it directly damages the adrenal cortex and reduces the production of cortisol and other steroids.
Reference(s):
1. Waszut U et al. (2017). Understanding mitotane mode of action. J Physiol Pharmacol.
2. Broersen LHA et al. (2018). Effectiveness of medical treatment for Cushing's syndrome: a systematic review and meta-analysis. Pituitary.
bottom of page