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The Sound of Evolution
Mivacurium
Mechanism of action:
Mivacurium is a benzylisoquinolinium derivative. Mivacurium competitively blocks nicotinic acetylcholine receptors at the motor end-plate, preventing acetylcholine from exerting its effect. As a result, action potentials cannot be generated, leading to skeletal muscle relaxation.
Reference(s):
1. Ihmsen H et al. (2009). Influence of disease progression on the neuromuscular blocking effect of mivacurium in children and adolescents with Duchenne muscular dystrophy. Anesthesiology.
2. Jonsson Fagerlund M et al. (2009). Pharmacological characteristics of the inhibition of nondepolarizing neuromuscular blocking agents at human adult muscle nicotinic acetylcholine receptor. Anesthesiology.
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