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The Sound of Evolution
Moclobemide
Mechanism of action:
Moclobemide is a reversible monoamine oxidase A inhibitor. Moclobemide reversibly and selectively inhibits monoamine oxidase A, thereby reducing the breakdown of serotonin (5-HT) and norepinephrine (NE), increasing their concentrations in the synaptic cleft, and prolonging the duration of neurotransmitter action.
Reference(s):
1. Bonnet U et al. (2003). Moclobemide: therapeutic use and clinical studies. CNS Drug Rev.
2. Gram LF et al. (1995). Moclobemide, a substrate of CYP2C19 and an inhibitor of CYP2C19, CYP2D6, and CYP1A2: a panel study. Clin Pharmacol Ther.
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