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The Sound of Evolution
Mosapride
Mechanism of action:
Mosapride is a 5-HT₄ receptor agonist. Mosapride mainly acts on 5-HT₄ receptors in the enteric nervous system, stimulating enteric nerve terminals to release acetylcholine. This subsequently promotes smooth muscle contraction, increases lower esophageal sphincter tone, and enhances coordinated contractions of the gastric antrum and duodenum.
Reference(s):
1. Zhou Y et al. (2024). TTD: Therapeutic Target Database describing target druggability information. Nucleic Acids Res.
2. Langlois M et al. (2003). 5-HT4 receptor ligands: applications and new prospects. J Med Chem.
3. Liu T et al. (2025). BindingDB in 2024: a FAIR knowledgebase of protein-small molecule binding data. Nucleic Acids Res.
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