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The Sound of Evolution
Mupirocin
Mechanism of action:
Mupirocin is a pseudomonic acid derivative. Mupirocin highly selectively blocks bacterial isoleucyl-tRNA synthetase, preventing isoleucine from being attached to tRNA. As a result, bacteria cannot properly elongate protein chains, leading to inhibition of protein synthesis and suppression of bacterial growth.
Reference(s):
1. Parenti MA et al. (1987). Mupirocin: a topical antibiotic with a unique structure and mechanism of action. Clin Pharm.
2. Putnam CD et al. (1989). Mupirocin: a new topical therapy for impetigo. J Pediatr Health Care.
3. Lamb YJ et al. (1991). Overview of the role of mupirocin. J Hosp Infect.
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