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The Sound of Evolution
Mycophenolate
Mechanism of action:
Mycophenolate is an inosine monophosphate dehydrogenase inhibitor and is a mycophenolic acid derivative. Mycophenolate inhibits inosine monophosphate dehydrogenase, thereby blocking the synthesis of xanthosine monophosphate and consequently suppressing the synthesis of guanosine monophosphate. This has an inhibitory effect on lymphocytes, which require rapid proliferation during immune responses.
Reference(s):
1. Kitchin JE et al. (1997). Rediscovering mycophenolic acid: a review of its mechanism, side effects, and potential uses. J Am Acad Dermatol.
2. Shaw LM et al. (2003). Mycophenolic acid pharmacodynamics and pharmacokinetics provide a basis for rational monitoring strategies. Am J Transplant.
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